Highly Sensitive Magnetic Sensing of Neural Activity

Mürsel Karadas

Research focus
Nitrogen-vacancy (NV) centers in diamond are a novel and quickly developing method to sensing magnetic fields at very high sensitivities. They work at room temperature and offer the possibility to perform
magnetometry at an excellent spatial resolution. This can be achieved by embedding a layer of NV centers in a planar diamond substrate and placing it on a commercially available CCD or CMOS imaging sensor. This setup allows reading out the NV fluorescence as a signal of the magnetic field strengths at the temporal and spatial resolution offered by the imaging sensor.

The in vitro recording of electrical neural activity of cell cultures or brain slices is a mainstay of neuroscience research. It fuels fundamental discoveries in neuroscience such as on the role of neurotransmitters and –modulators in long-term potentiation or depression of synaptic connections as a likely proxy for learning and adaptation effects.

The purpose of the project is to contribute the development of a setup for the in vitro recording and the analysis of neural activity based on magnetometry using NV centers. It is part of the EXMAD - Extreme Sensitive Magnetometry using Nitrogen-Vacancy Centers in Diamond project. EXMAD is a collaborative project involving researchers from DTU Physics, DTU Elektro, Philips BioCell and Ulm University. PI is Professor Ulrik Lund from DTU Physics.

Scientific output
Find Mürsel's publications at DTU's online research database ORBIT.

Funding
The project is funded by Innovation Fund Denmark (prev. Strategic Research Council) (File No. 1311-00006).

Supervisors
Associate Professor Axel Thielscher and Associate Professor Lars G. Hanson with Professor Ulrik Lund, DTU Physics.

Project Period
February 2016 - January 2019


Read more about EXMAD, the research project Mürsel is working on with DTU Physics.

Contact

Mürsel Karadas
PhD student
DTU Health Tech
http://www.cmr.healthtech.dtu.dk/research/phd-projects/mursel-karadas
15 DECEMBER 2019